The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28112925 |
44 |
Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells. |
University of Tennessee Health Science Center |
27774128 |
38 |
Discovery of ONO-7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead. |
Ono Pharmaceutical |
25746814 |
80 |
Discovery of novel S1P2 antagonists. Part 1: discovery of 1,3-bis(aryloxy)benzene derivatives. |
Ono Pharmaceutical |
25100502 |
15 |
Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor. |
The University of Tennessee Health Science Center |
25155385 |
10 |
Discovery of novel non-carboxylic acid 5-amino-4-cyanopyrazole derivatives as potent and highly selective LPA1R antagonists. |
Hoffmann-La Roche |
23395664 |
66 |
Phosphorothioate analogs of sn-2 radyl lysophosphatidic acid (LPA): metabolically stabilized LPA receptor agonists. |
The University of Utah |
22894757 |
69 |
Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts. |
F. Hoffmann-La Roche |
18178086 |
26 |
Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. |
Amgen |
20056548 |
4 |
Synthesis, in vitro structure-activity relationship, and in vivo studies of 2-arylthiazolidine-4-carboxylic acid amides as anticancer agents. |
University of Tennessee Health Science Center |
19800804 |
19 |
Structure-based drug design identifies novel LPA3 antagonists. |
The University of Memphis |
18467108 |
26 |
Identification of non-lipid LPA3 antagonists by virtual screening. |
The University of Memphis |
17467986 |
24 |
Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists. |
Ajinomoto |
16913720 |
15 |
Phosphonothioate and fluoromethylene phosphonate analogues of cyclic phosphatidic acid: Novel antagonists of lysophosphatidic acid receptors. |
The University of Utah |
16290140 |
54 |
Identification of Darmstoff analogs as selective agonists and antagonists of lysophosphatidic acid receptors. |
University of Tennessee Health Science Center |
16263282 |
43 |
Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands. |
University of Tennessee Health Science Center |
16033271 |
81 |
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. |
University of Tennessee Health Science Center |
15225728 |
55 |
A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a nonhydrolyzable LPA3 receptor-selective antagonist. |
University of Virginia |
15177455 |
27 |
Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid. |
Oxford University |
15125924 |
63 |
Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist. |
University of Virginia |
32584034 |
38 |
Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry. |
X-Chem |
31790581 |
23 |
A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA |
Universidad Complutense De Madrid |
31620221 |
6 |
Lysophosphatidic Acid Receptor 1 Antagonists for the Treatment of Fibrosis. |
Therachem Research Medilab |
22180836 |
5 |
Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist. |
University of Virginia |
29259748 |
32 |
Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia. |
Ono Pharmaceutical |